LABORATORY EVALUATION OF 0.025% WARFARIN AGAINST RATTUS TIOMANICUS

C.H. LEE AND MD. D. MUSTAFA

SUMMARY

Laboratory feeding tests were conducted to determine the efficacy of 0.025% warfarin against Rattus tiomanicus trapped from cocoa-coconut fields in Mardi Research Station in Hilir Perak. No-choice feeding periods of 2, 4,6,8 and 10 days gave mortalities of 25, 45, 80. 95 and 100% respectively for the pooled data. Mark variation in susceptibility to warfarin among the individuals was noted. The lethal feeding period (LFP₅₀) with 95% fiducial limits were 3.20 days for females and 3.77 days for males. No significant difference was found between the mean of the two sexes and the data was pooled for probit analysis. This provided a base-line on the susceptibility of R. tiomanicus to warfarin. The upper 95% fiducial limit calculated for the LFP 95 indicated that survival following a 14-day feeding period on 0.025% warfarin bait is a suitable test for detecting warfarin resistance.

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